Description

N6-Benzoyl-3'-Deoxyadenosine is a chemically modified nucleoside derivative, specifically an N6-benzoylated 3'-deoxyadenosine analog. This compound serves as a crucial building block and protecting group intermediate in the synthesis of oligonucleotides and nucleotide-based pharmaceuticals. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic agents, including antisense oligonucleotides and prodrugs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of modified nucleoside analogs for antiviral and anticancer drug development.
• Oligonucleotide Synthesis: Used as a protected monomer in solid-phase synthesis for research-scale and therapeutic oligonucleotide production.
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics, nucleic acid metabolism, and polymerase activity.
• Prodrug Development: Employed in the design of nucleotide prodrugs to enhance cellular uptake and metabolic stability.
• Antisense Technology: A component in the creation of antisense oligonucleotides for targeted gene silencing applications.
• Labeling and Detection: Can be used to introduce reporter groups or tags into nucleic acid sequences for diagnostic assays.

Basic Information

Product Name	N6-Benzoyl-3'-Deoxyadenosine
CAS No.	76902-49-3
Molecular Formula	C17H17N5O4
Molecular Weight	355.35 g/mol
Synonyms	3'-Deoxy-N6-benzoyladenosine; 3'-Deoxyadenosine, N6-benzoyl-; N6-Benzoyl-3'-deoxyadenosine; 9-[(2R,5S)-5-(Hydroxymethyl)oxolan-2-yl]-N-phenyl-9H-purin-6-amine; Bz-dA; N6-Bz-3'-dA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our N6-Benzoyl-3'-Deoxyadenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our quality system supports compliance with global regulatory standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light); therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.