Description

1-Oxaspiro[2.5]Octane-2-Carbonyl Chloride (9Ci) is a specialized spirocyclic organic building block featuring a highly reactive acid chloride functional group. This compound is valued for its unique bridged-ring structure, which serves as a critical intermediate in the synthesis of complex molecules. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly those requiring spirocyclic or bridged-ring scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its unique structure can impart specific biological activity.
• Material Science Research: Serves as a precursor for creating specialized polymers, ligands, or functional materials with tailored properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing complex natural product analogs and other intricate organic molecules.
• Cross-Coupling & Derivatization Reactions: The reactive carbonyl chloride group facilitates further functionalization through amidation, esterification, or other nucleophilic substitution reactions.

Basic Information

Product Name	1-Oxaspiro[2.5]Octane-2-Carbonyl Chloride (9Ci)
CAS No.	76527-44-1
Molecular Formula	C8H11ClO2
Molecular Weight	174.62 g/mol
Synonyms	1-Oxaspiro[2.5]octane-2-carbonyl chloride; 1-Oxaspiro(2.5)octane-2-carbonyl chloride; 2-Oxaspiro[3.5]nonane-3-carbonyl chloride (alternative numbering); Spiro[2.5]octane-1-carbonyl chloride, 2-oxo-; Oxaspirooctanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1-Oxaspiro[2.5]Octane-2-Carbonyl Chloride adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is characterized and tested using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, it should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage. Recommended storage temperature is 2-8°C. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.