Description

5-(Trifluoromethyl)Cytidine is a modified nucleoside analog where a trifluoromethyl group is introduced at the 5-position of the cytosine base. This compound is of significant interest in pharmaceutical research and development due to its potential to alter the metabolic stability, lipophilicity, and binding affinity of oligonucleotides. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, medicinal chemistry, and oligonucleotide synthesis for developing novel therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified oligonucleotides, including antisense oligonucleotides (ASOs) and siRNA.
• Medicinal Chemistry Research: Used to study structure-activity relationships (SAR) by incorporating the trifluoromethyl group to modulate the properties of nucleoside-based drug candidates.
• Proteomics & Diagnostics: Potential application in the development of labeled nucleosides for diagnostic assays and biomolecular probes.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.
• Antiviral/Anticancer Agent Development: Exploration of its incorporation into nucleoside analogs for evaluating antiviral or anticancer activity.

Basic Information

Product Name	5-(Trifluoromethyl)Cytidine
CAS No.	76514-02-8
Molecular Formula	C10H12F3N3O5
Molecular Weight	311.21 g/mol
Synonyms	5-Trifluoromethylcytidine; 1-β-D-Ribofuranosyl-5-(trifluoromethyl)cytosine; 5-CF3-Cytidine; 5-(Trifluoromethyl)-1-β-D-ribofuranosylcytosine; 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidin-2-one
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Cytidine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.