Description

8-(Trifluoromethyl)Adenosine is a modified nucleoside analog where a trifluoromethyl group is introduced at the 8-position of the adenine base. This compound is a critical building block in medicinal chemistry and pharmaceutical research, valued for its ability to alter the metabolic stability and binding affinity of nucleotide-based therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and novel biochemical probes.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to enhance the metabolic stability and efficacy of drug candidates.
• Proteomics & Molecular Biology: Can be incorporated into oligonucleotides for studying RNA structure, function, and protein-nucleic acid interactions.
• Diagnostic Agent Development: Potential use in creating labeled probes for imaging or diagnostic assays.

Basic Information

Product Name	8-(Trifluoromethyl)Adenosine
CAS No.	76513-89-8
Molecular Formula	C11H12F3N5O4
Molecular Weight	335.24 g/mol
Synonyms	8-(Trifluoromethyl)adenosine; 9-β-D-Ribofuranosyl-8-(trifluoromethyl)adenine; Adenosine, 8-(trifluoromethyl)-; 8-Trifluoromethyladenosine; 8-CF3-Adenosine; 8-(Trifluoromethyl)-9H-purin-6-amine riboside
EINECS	Contact for details

Quality Control

Our 8-(Trifluoromethyl)Adenosine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions of 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.