Description

2',3',5'-Tri-o-Acetyl-8-Trifluoromethyl Adenosine is a chemically modified nucleoside derivative, specifically an acetyl-protected adenosine analog featuring a trifluoromethyl group at the 8-position. This compound is a critical high-purity building block in pharmaceutical research and development, enabling the synthesis of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and CROs/CDMOs engaged in antiviral drug discovery, nucleotide chemistry, and the development of modified RNA/DNA analogs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating the structure-activity relationships (SAR) of modified nucleosides and their interaction with enzymes.
• Pro-drug Development: The acetyl groups serve as protecting groups, making it a valuable intermediate for creating bio-activatable pro-drug forms of active nucleoside compounds.
• Labeled Compound Synthesis: Serves as a starting material for introducing the 8-trifluoromethyl-adenosine moiety into more complex molecules, including those with isotopic labels.
• Nucleotide Chemistry: Employed in the preparation of modified nucleotides for oligonucleotide synthesis and aptamer development.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-8-Trifluoromethyl Adenosine
CAS No.	76513-88-7
Molecular Formula	C19H19F3N5O7
Molecular Weight	501.38 g/mol
Synonyms	8-Trifluoromethyladenosine 2',3',5'-triacetate; 8-(Trifluoromethyl)adenosine 2',3',5'-tri-O-acetate; N6-[(1S,2R,3S,4R,5S)-4-Acetoxy-2,3-diacetoxy-6,8-dioxabicyclo[3.2.1]oct-1-yl]-8-(trifluoromethyl)-9H-purin-6-amine; 8-CF3-Ado-2',3',5'-triacetate; 2',3',5'-Tri-O-acetyl-8-(trifluoromethyl)adenosine
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-8-Trifluoromethyl Adenosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.