Description

5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxycytidine is a key protected nucleoside derivative, essential for the controlled synthesis of oligonucleotides. This compound matters because it provides a critical building block for creating DNA sequences with high precision and yield, enabling advanced research and therapeutic development. It is primarily needed by pharmaceutical companies, biotechnology research institutions, and diagnostic manufacturers engaged in antisense therapy, PCR, and next-generation sequencing applications.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a fundamental phosphoramidite precursor for the automated synthesis of DNA strands.
• Antisense Oligonucleotide (ASO) Production: Used in the manufacture of therapeutic oligonucleotides for targeting specific RNA sequences.
• Polymerase Chain Reaction (PCR) Probe Development: Acts as a starting material for synthesizing labeled probes and primers.
• Next-Generation Sequencing (NGS): Employed in the preparation of specialized nucleotides for sequencing platforms.
• Research & Development: Utilized in academic and industrial labs for studying nucleic acid chemistry and developing novel genetic tools.
• Diagnostic Kit Manufacturing: A critical raw material for producing in-vitro diagnostic (IVD) components that rely on specific DNA hybridization.

Basic Information

Product Name	5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxycytidine
CAS No.	76512-82-8
Molecular Formula	C32H35N3O7
Molecular Weight	573.64 g/mol
Synonyms	5'-O-DMT-2'-deoxycytidine; DMT-dC; N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (common protected form); 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine; 1-[(2R,4S,5R)-4-Hydroxy-5-[(hydroxy(4-methoxyphenyl)(4-methoxyphenyl)phenylmethoxy)methyl]oxolan-2-yl]-4-aminopyrimidin-2-one; DMTr-dC; 5'-O-(Bis(4-methoxyphenyl)phenylmethyl)-2'-deoxycytidine
EINECS	Contact for details

Quality Control

Our 5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxycytidine is manufactured under strict quality systems suitable for pharmaceutical intermediates. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) detailing purity, moisture content, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in acetonitrile, DMF, pyridine

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.