Description

(5'-(Tryptaminocarbonyl)-2'-Deoxyribofuranosyl)Thymine is a sophisticated nucleoside derivative that serves as a critical building block in advanced biochemical research and pharmaceutical development. This compound is valued for its unique structure, which combines a thymine base with a tryptamine-derived side chain, enabling specific interactions in nucleic acid chemistry and targeted drug design. It is primarily sought by researchers and developers in the fields of nucleic acid synthesis, medicinal chemistry, and molecular biology for creating novel probes, therapeutic candidates, and modified oligonucleotides.

Application

• Nucleic Acid Research: Used as a modified nucleoside precursor in the synthesis of oligonucleotides with tailored properties for diagnostic assays and structural studies.
• Medicinal Chemistry: Serves as a key intermediate in the development of novel antiviral and anticancer agents that target DNA replication and repair mechanisms.
• Bioconjugation: The tryptaminocarbonyl moiety provides a handle for attaching fluorophores, affinity tags, or other functional groups to nucleic acid strands.
• Enzyme Substrate Studies: Employed in biochemical assays to study the activity and inhibition of nucleoside-processing enzymes like kinases and polymerases.
• Prodrug Development: Investigated for creating prodrugs designed for targeted delivery and controlled release of therapeutic nucleoside analogs.

Basic Information

Product Name	(5'-(Tryptaminocarbonyl)-2'-Deoxyribofuranosyl)Thymine
CAS No.	76500-11-3
Molecular Formula	C19H22N4O6
Molecular Weight	402.40 g/mol
Synonyms	5'-(Tryptaminocarbonyl)thymidine; 5'-O-[N-(Tryptaminocarbonyl)]thymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione 5'-[3-(1H-indol-3-yl)propylcarbamate]; Thymidine 5'-(3-indolylpropylcarbamate); 5'-O-(N-Tryptaminocarbonyl)thymidine
EINECS	Contact for details

Quality Control

Our (5'-(Tryptaminocarbonyl)-2'-Deoxyribofuranosyl)Thymine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. All materials are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' development and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.