Description

1H-Benzimidazole, 1-(3,5-o-Phosphinico-β-D-Ribofuranosyl)- is a specialized nucleoside analog with a benzimidazole base linked to a modified ribose sugar via a phosphinico group. This unique structure makes it a valuable intermediate for the development of novel antiviral and anticancer agents, particularly in nucleotide-based therapeutics. It is essential for pharmaceutical R&D and fine chemical synthesis targeting RNA virus inhibition and enzyme modulation. The compound, identified by CAS No. 76461-19-3, is supplied to meet the stringent purity demands of advanced life science applications.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of experimental nucleoside analog drugs targeting viral polymerases.
• Antiviral Research: Used in the development of potential therapeutic agents against RNA viruses, including hepatitis C and coronaviruses.
• Oncology Research: Serves as a precursor for prodrugs designed to interfere with cancer cell DNA/RNA synthesis.
• Biochemical Tool Compound: Employed in enzymatic studies to investigate the mechanism of action of nucleotide-binding proteins.
• Fine Chemical Synthesis: A versatile synthon for creating complex molecules with modified sugar-phosphate backbones for structure-activity relationship (SAR) studies.
• Preclinical Development: Supports the early-stage development and scale-up of new chemical entities (NCEs) in drug discovery pipelines.

Basic Information

Product Name	1H-Benzimidazole, 1-(3,5-o-Phosphinico-β-D-Ribofuranosyl)-
CAS No.	76461-19-3
Molecular Formula	C12H16N3O7P
Molecular Weight	345.25 g/mol
Synonyms	1-(3,5-O-Phosphinico-β-D-ribofuranosyl)benzimidazole; 1-(3,5-Di-O-phosphino-β-D-ribofuranosyl)-1H-benzimidazole; Benzimidazole nucleoside phosphinate; 1-(β-D-Ribofuranosyl)benzimidazole 3',5'-cyclic phosphoramidate (related analog); BzRib-P; Nucleoside benzimidazole derivative; 76461-19-3; 1H-Benzimidazole, 1-(3,5-di-O-phosphino-β-D-ribofuranosyl)-
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 1-(3,5-o-Phosphinico-β-D-Ribofuranosyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.