Description

Thyroxine Ethyl Ester is a chemically modified derivative of the thyroid hormone thyroxine (T4), where the carboxylic acid group is esterified with ethanol. This modification is crucial for enhancing the compound's lipophilicity and membrane permeability, making it a valuable pharmaceutical intermediate and research biochemical. It is primarily utilized in the development and production of thyroid hormone analogs, metabolic research, and as a key starting material in advanced synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel thyroid hormone receptor agonists and antagonists for therapeutic development.
• Biochemical Research: Used in metabolic studies, endocrinology research, and investigations into thyroid hormone action and transport mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.
• Prodrug Synthesis: Acts as a building block for creating prodrug forms of thyroid hormones to improve bioavailability and pharmacokinetic profiles.
• Academic & Industrial R&D: Employed in discovery chemistry for creating labeled compounds (e.g., isotopic, fluorescent) for tracing and imaging studies.

Basic Information

Product Name	Thyroxine Ethyl Ester
CAS No.	76353-71-4
Molecular Formula	C17H17I4NO4
Molecular Weight	821.04 g/mol
Synonyms	L-Thyroxine ethyl ester; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine ethyl ester; T4 Ethyl Ester; Thyroxine O-ethyl ester; 3,3',5,5'-Tetraiodothyronine ethyl ester; Ethyl L-thyroxinate; Levothyroxine ethyl ester
EINECS	Contact for details

Quality Control

Our Thyroxine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results from HPLC, NMR, and IR spectroscopy. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.