Description

Sodium 4-Isothiocyanatobenzenesulfonate is a versatile chemical intermediate featuring both a reactive isothiocyanate group and a water-solubilizing sulfonate moiety. This unique bifunctional structure makes it a critical building block for the synthesis of specialized compounds requiring aqueous compatibility and selective conjugation. It is primarily sought after by research institutions and manufacturers in the life sciences and specialty chemical sectors. The compound enables the development of advanced materials, diagnostic reagents, and biologically active molecules through its reliable coupling chemistry.

Application

• Bioconjugation Reagent: Used for labeling proteins, antibodies, and peptides via stable thiourea bond formation, essential for diagnostic assay development and biopharmaceutical research.
• Polymer Modification: Serves as a functional monomer or cross-linker for introducing reactive sites or sulfonate groups into polymers, enhancing hydrophilicity and functionality.
• Chromatography Ligand Synthesis: A key precursor for creating affinity chromatography media by immobilizing ligands onto solid supports for protein purification.
• Fluorescent Probe & Dye Intermediate: Employed in the synthesis of water-soluble fluorescent dyes and probes for cellular imaging and sensor applications.
• Pharmaceutical Intermediate: Utilized in the research and development of novel drug candidates, particularly those requiring targeted delivery or specific solubility profiles.
• Surface Functionalization: Applied to modify the surface of nanoparticles, quantum dots, or other nanomaterials to improve biocompatibility and enable further chemical attachment.

Basic Information

Product Name	Sodium 4-Isothiocyanatobenzenesulfonate
CAS No.	76274-62-9
Molecular Formula	C7H4NNaO3S2
Molecular Weight	245.23 g/mol
Synonyms	4-Isothiocyanatobenzenesulfonic Acid Sodium Salt; Benzenesulfonic Acid, 4-Isothiocyanato-, Sodium Salt; Sodium 4-Isothiocyanatobenzene-1-sulfonate; p-Isothiocyanatobenzenesulfonate Sodium Salt; Sodium p-Isothiocyanatobenzenesulfonate; 4-(Isothiocyanato)benzenesulfonic Acid Sodium Salt; Sodium Sulfonate Phenyl Isothiocyanate; SPITC
EINECS	Contact for details

Quality Control

Our Sodium 4-Isothiocyanatobenzenesulfonate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and amines.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.