Description

3-Methyl-2'-Deoxyadenosine is a chemically modified nucleoside analog, a key building block in nucleic acid research and pharmaceutical development. This compound is valued for its role in studying DNA structure, function, and the mechanisms of enzymatic methylation, which are critical in epigenetics and oncology research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of nucleotide-based therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving DNA methyltransferases and polymerases.
• Probe Development: Serves as a modified building block for creating labeled DNA probes and primers used in molecular diagnostics and sequencing.
• Epigenetics Studies: Employed to investigate the biological impact and mechanisms of specific methylation patterns on DNA.
• Standards & References: Acts as a certified reference material (CRM) or analytical standard for quality control in nucleotide manufacturing.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotides to modulate their stability, binding affinity, and biological activity.

Basic Information

Product Name	3-Methyl-2'-Deoxyadenosine
CAS No.	76227-25-3
Molecular Formula	C11H15N5O3
Molecular Weight	265.27 g/mol
Synonyms	N3-Methyl-2'-deoxyadenosine; 3-Methyl-2'-deoxyadenosine; 3-Methyladenine deoxyriboside; 2'-Deoxy-3-methyladenosine; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-3-methyl-9H-purin-6-amine; 3-Me-dA; N3-Methyl-2'-deoxyadenosine; 3-Methyl-2'-deoxyadenosine (3-Me-dA)
EINECS	Contact for details

Quality Control

Our 3-Methyl-2'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.