Description

Fenretinide Glucuronide Monosodium Salt is a water-soluble, conjugated metabolite of the synthetic retinoid fenretinide. This compound is of significant interest for its role in drug metabolism studies and as a reference standard in analytical chemistry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on oncology and metabolic pathway research.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantification and identification of fenretinide metabolites in biological matrices via HPLC, LC-MS, or other analytical methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance mechanisms of fenretinide in preclinical and clinical research.
• Biochemical Research: Serves as a critical tool in studies exploring the mechanisms of action of retinoids and their glucuronidated derivatives in cell signaling and apoptosis.
• Analytical Method Development: Employed for the development, validation, and calibration of bioanalytical assays in compliance with GLP guidelines.
• Impurity Profiling: Used to identify and quantify related substances and degradation products in fenretinide active pharmaceutical ingredient (API) batches.

Basic Information

Item	Details
Product Name	Fenretinide Glucuronide Monosodium Salt
CAS No.	76177-99-6
Molecular Formula	C34H43NO9•Na
Molecular Weight	632.70 g/mol
Synonyms	N-(4-Hydroxyphenyl)retinamide Glucuronide Sodium Salt; 4-HPR Glucuronide Sodium Salt; Fenretinide β-D-Glucuronide Sodium Salt; Fenretinide Glucuronide Sodium; (all-E)-N-(4-Hydroxyphenyl)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenamide Glucuronide Sodium Salt
EINECS	Contact for details

Quality Control

Every batch of Fenretinide Glucuronide Monosodium Salt is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications for identity, purity, and potency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming the results of tests including HPLC assay, related substances, residual solvents, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.