Description

4-Trimethylsilyl-n-Phenylbutanamide is a specialized organosilicon compound featuring a phenylbutanamide backbone protected by a trimethylsilyl (TMS) group. This unique structure makes it a valuable intermediate and protecting group reagent in advanced synthetic chemistry, particularly for modifying amide functionalities. It is primarily utilized by pharmaceutical and agrochemical R&D teams engaged in the synthesis of novel active ingredients and fine chemicals where precise control over molecular architecture is critical.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those requiring amide protection/deprotection strategies.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides where the silyl group aids in selective reactions.
• Peptide & Protein Chemistry: Serves as a protecting agent for amide bonds during solid-phase peptide synthesis (SPPS) and other bioconjugation processes.
• Material Science Research: Intermediate for creating novel silicon-containing polymers or surface-modifying agents with specific organic functionalities.
• Organic Synthesis Reagent: Employed as a versatile reagent in academic and industrial labs for nucleophilic substitution reactions and the preparation of silylated derivatives.

Basic Information

Product Name	4-Trimethylsilyl-n-Phenylbutanamide
CAS No.	76149-46-7
Molecular Formula	C₁₃H₂₁NOSi
Molecular Weight	235.40 g/mol
Synonyms	N-Phenyl-4-(trimethylsilyl)butyramide; 4-(Trimethylsilyl)-N-phenylbutanamide; Butanamide, 4-(trimethylsilyl)-N-phenyl-; 4-Trimethylsilyl-N-phenylbutyramide; TMS-Phenylbutanamide; 76149-46-7; 4-(Trimethylsilyl)butyranilide
EINECS	Contact for details

Quality Control

Our production of 4-Trimethylsilyl-n-Phenylbutanamide adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.