Description

n-D-Ornithylamphotericin B Methyl Ester is a semi-synthetic derivative of the potent polyene macrolide antibiotic, amphotericin B. This modified compound is engineered to potentially enhance solubility and alter the pharmacological profile for advanced research and development applications. It is primarily utilized by pharmaceutical R&D laboratories and academic institutions focused on antifungal drug discovery, novel formulation strategies, and structure-activity relationship (SAR) studies.

Application

• Antifungal Drug Discovery & Development: Serves as a key intermediate or lead compound for synthesizing novel antifungal agents with potentially improved efficacy or reduced toxicity profiles.
• Pharmaceutical Research: Used in biochemical and microbiological assays to study mechanisms of action against fungal pathogens, particularly for investigating membrane-targeting polyenes.
• Structure-Activity Relationship (SAR) Studies: Essential for medicinal chemistry programs aiming to understand how chemical modifications to the amphotericin B core structure influence biological activity and physicochemical properties.
• Academic & Institutional Research: Employed in university and government laboratories for fundamental research on polyene antibiotics and fungal cell membrane biology.
• Reference Standard: Can be used as a high-purity analytical standard for method development and quality control in related pharmaceutical analysis.

Basic Information

Product Name	n-D-Ornithylamphotericin B Methyl Ester
CAS No.	76023-49-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N-D-Ornithylamphotericin B Methyl Ester; Amphotericin B N-D-Ornithyl Methyl Ester; Methyl N-D-Ornithylamphotericin B; Ornithylamphotericin B Methyl Ester; Amphotericin B Ornithyl Methyl Ester Derivative; Polyene Antibiotic Derivative; CAS 76023-49-9
EINECS	Contact for details

Quality Control

Our n-D-Ornithylamphotericin B Methyl Ester is produced under controlled conditions suitable for research applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. While specific pharmacopeial standards (USP, EP) may not be defined for this research chemical, we provide comprehensive analytical data. A Certificate of Analysis (COA) detailing purity (typically by HPLC), identification, and other relevant parameters is available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.