Description

5'-Trt-N6-Bz-2'-Da is a protected nucleoside derivative, specifically a 2'-deoxyadenosine analog, widely used as a critical building block in oligonucleotide synthesis. Its value lies in providing precise control over the assembly of DNA sequences by protecting key functional groups during automated solid-phase synthesis. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries developing advanced therapeutics, probes, and molecular tools.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated solid-phase synthesis of DNA strands.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications.
• PCR Primer and Probe Manufacture: Enables the production of high-fidelity primers and labeled probes for diagnostic assays and genetic testing.
• siRNA and miRNA Synthesis: Serves as a building block for RNA interference (RNAi) research and therapeutic agent development.
• Chemical Biology Research: Employed in the study of nucleic acid structure, function, and protein-nucleic acid interactions.
• Diagnostic Kit Component: Integral to manufacturing components for molecular diagnostic kits and next-generation sequencing (NGS) platforms.

Basic Information

Product Name	5'-Trt-N6-Bz-2'-Da
CAS No.	75759-62-5
Molecular Formula	C32H29N5O4
Molecular Weight	547.60 g/mol
Synonyms	5'-O-Trityl-N6-benzoyl-2'-deoxyadenosine; N6-Benzoyl-5'-O-trityl-2'-deoxyadenosine; 2'-Deoxy-N6-benzoyl-5'-O-trityladenosine; 5'-O-(Triphenylmethyl)-N6-benzoyl-2'-deoxyadenosine; N6-Bz-5'-O-DMT-2'-dA; dA(Bz)-5'-DMT; Protected 2'-Deoxyadenosine; DNA Synthesis Building Block
EINECS	Contact for details

Quality Control

Our 5'-Trt-N6-Bz-2'-Da is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to industry best practices and can support development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and performance. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.