Description

4-Isoxazolecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci) is a high-purity, reactive chemical intermediate featuring a trifluoromethyl-substituted isoxazole core. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the efficient introduction of the pharmacologically important trifluoromethyl group and isoxazole heterocycle. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, or organic electronic materials that require specific heterocyclic and fluorinated components.
• Chemical Biology Probes: Employed in the synthesis of labeled compounds or activity-based probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	4-Isoxazolecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci)
CAS No.	75706-01-3
Molecular Formula	C5H1ClF3NO2
Molecular Weight	199.51 g/mol
Synonyms	5-(Trifluoromethyl)-4-isoxazolecarbonyl chloride; 5-(Trifluoromethyl)isoxazole-4-carbonyl chloride; 4-Isoxazolecarbonyl chloride, 5-(trifluoromethyl)-; 5-Trifluoromethyl-4-isoxazolecarboxylic acid chloride; 5-Trifluoromethylisoxazole-4-carbonyl chloride; 5-Trifluoromethyl-1,2-oxazole-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Isoxazolecarbonyl Chloride, 5-(Trifluoromethyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.