Description

5-Isothiocyanato-1,10-Phenanthroline is a versatile heterocyclic organic compound that serves as a critical bifunctional chelating agent and molecular scaffold. Its core value lies in the unique combination of a rigid phenanthroline backbone, which strongly coordinates to metal ions, and a reactive isothiocyanate group for covalent conjugation to biomolecules. This product is essential for researchers and manufacturers in the fields of analytical chemistry, materials science, and pharmaceutical development, where precise molecular assembly and metal complexation are required.

Application

• Fluorescent Probe Synthesis: Acts as a key precursor for creating highly sensitive and selective luminescent sensors for metal ion detection (e.g., Zn²⁺, Cu²⁺, Fe²⁺) in biological and environmental samples.
• Bioconjugation & Labeling Reagent: The isothiocyanate group readily reacts with amine groups on proteins, antibodies, or peptides, enabling the site-specific attachment of a metal-chelating phenanthroline tag for diagnostic or therapeutic applications.
• Catalyst Ligand Preparation: Used to synthesize novel transition metal complexes that serve as catalysts for organic synthesis reactions, including oxidation and coupling processes.
• Electrochemical Sensor Development: Incorporated into modified electrodes to enhance selectivity and sensitivity for the electrochemical detection of specific analytes.
• Polymer & Material Functionalization: Employed to introduce metal-binding sites onto polymer chains or material surfaces, creating smart materials with tailored properties.
• Research & Development: Serves as a fundamental building block in academic and industrial R&D for exploring new coordination chemistry, supramolecular assemblies, and photophysical properties.

Basic Information

Product Name	5-Isothiocyanato-1,10-Phenanthroline
CAS No.	75618-99-4
Molecular Formula	C₁₃H₇N₃S
Molecular Weight	237.28 g/mol
Synonyms	5-Isothiocyanato-1,10-phenanthroline; 1,10-Phenanthroline-5-isothiocyanate; 5-ITC-Phen; Phen-ITC; 5-Isothiocyanatophenanthroline; 5-(Isothiocyanato)-1,10-phenanthroline; 5-NCS-1,10-phenanthroline; 1,10-Phenanthrolin-5-yl isothiocyanate
EINECS	Contact for details

Quality Control

Every batch of 5-Isothiocyanato-1,10-Phenanthroline is subjected to rigorous analytical testing to ensure high purity and consistent performance. Our quality assurance protocols are designed to meet the stringent requirements of research and industrial applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.