Description

5,6-Dichloro-1-(β-Ribofuranosyl)Benzimidazole 2'-Phosphate is a specialized nucleoside analog derivative, primarily recognized for its role as a key intermediate in pharmaceutical research and development. This compound is critical for scientists developing novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular enzymes. It is essential for research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of modified nucleosides and nucleotide-based prodrugs.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases and polymerases.
• Prodrug Development: Serves as a phosphate-protected precursor in the design of nucleotide prodrugs to enhance bioavailability.
• Antiviral Agent Synthesis: Key starting material for research into broad-spectrum antiviral compounds, including potential treatments for DNA viruses.
• Labeled Compound Synthesis: Used in the preparation of radiolabeled or fluorescently tagged nucleotides for diagnostic and tracking applications.
• Chemical Biology Probes: Employed in the development of probes to study nucleic acid metabolism and related cellular pathways.

Basic Information

Product Name	5,6-Dichloro-1-(β-Ribofuranosyl)Benzimidazole 2'-Phosphate
CAS No.	75206-89-2
Molecular Formula	C12H13Cl2N2O7P
Molecular Weight	399.12 g/mol
Synonyms	5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole 2'-phosphate; 2'-Phosphoryl-5,6-dichlorobenzimidazole riboside; DRB 2'-Phosphate; 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole 2'-(dihydrogen phosphate); 1-(β-D-Ribofuranosyl)-5,6-dichlorobenzimidazole 2'-phosphate; 5,6-DCl-RibBz 2'-P; CAS 75206-89-2
EINECS	Contact for details

Quality Control

Our 5,6-Dichloro-1-(β-Ribofuranosyl)Benzimidazole 2'-Phosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical intermediate supply, supporting compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.