Description

Adenosine 5'-(2-Bromoethyl)Phosphate is a chemically modified nucleotide analog of significant interest in biochemical research and pharmaceutical development. Its core value lies in its reactive bromoethyl group, which serves as a versatile handle for cross-linking, affinity labeling, and the synthesis of more complex nucleotide conjugates. This compound is essential for researchers and manufacturers in nucleotide chemistry, enzymology, and medicinal chemistry, particularly for studying enzyme mechanisms and developing targeted therapeutic agents.

Application

• Biochemical Research: As a key intermediate in the synthesis of affinity labels and mechanism-based inhibitors for ATP-binding enzymes and kinases.
• Medicinal Chemistry: Used in the development of nucleotide-based prodrugs and targeted therapeutic conjugates.
• Enzymology Studies: Employed as an active site-directed irreversible inhibitor to probe the structure and function of adenylate-utilizing enzymes.
• Cross-linking Agent: Utilized for covalent modification of proteins and nucleic acids to study biomolecular interactions.
• Nucleotide Analog Synthesis: Serves as a crucial building block for creating novel modified nucleotides with specific biological activities.
• Diagnostic Reagent Development: Potential use in creating labeled probes for various detection and diagnostic assays.

Basic Information

Product Name	Adenosine 5'-(2-Bromoethyl)Phosphate
CAS No.	75203-44-0
Molecular Formula	C12H17BrN5O7P
Molecular Weight	454.17 g/mol
Synonyms	2-Bromoethyl Adenosine 5'-Monophosphate; 5'-(2-Bromoethyl) Adenosine Monophosphate; Adenosine 5'-Monophosphate 2-Bromoethyl Ester; 2-Bromoethyl AMP; BrEt-AMP; 9-β-D-Ribofuranosyladenine 5'-(2-bromoethyl)phosphate; 5'-O-[(2-Bromoethoxy)phosphoryl]adenosine
EINECS	Contact for details

Quality Control

Our Adenosine 5'-(2-Bromoethyl)Phosphate is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.