Description

Temarotene CAS NO 75078-91-0 is a synthetic retinoid compound, a class of molecules known for their potent biological activity in regulating cell growth and differentiation. Its primary value lies in its application as a key pharmaceutical intermediate for the development of dermatological and oncological treatments. This product is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of novel retinoid-based therapies. We supply high-purity Temarotene to support critical development and production processes globally.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced retinoid drugs for treating skin conditions like psoriasis and acne.
• Dermatological Research: Used in preclinical and clinical research to study mechanisms of action for new topical and systemic dermatological agents.
• Oncology Research: Investigated for its potential role in cancer therapy research, particularly in differentiation therapy for certain leukemia types.
• Biochemical Studies: Serves as a reference standard and active compound in studies of retinoid receptor (RAR/RXR) pathways and gene expression.
• Cosmeceutical Development: Employed in the R&D of high-performance anti-aging and skin-renewal formulations.

Basic Information

Product Name	Temarotene
CAS No.	75078-91-0
Molecular Formula	C23H28O2
Molecular Weight	336.47 g/mol
Synonyms	4-[(1E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propen-1-yl]benzoic Acid; Ro 15-1570; TTNN; Arotinoid Ethylester (related analog); Synthetic Retinoid; Retinoid-like compound; Temaroten; 4-[(E)-2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]benzoic Acid
EINECS	Contact for details

Quality Control

Our Temarotene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical use. Each lot undergoes comprehensive analytical testing including HPLC for assay and purity, identification by spectroscopic methods, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We can support development projects requiring compliance with ICH guidelines for impurities (Q3A/B).

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation, at a controlled room temperature of 15-25°C. Keep the container in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.