Description

3'-Fluoro-3'-Deoxyadenosine is a fluorinated nucleoside analog, a chemically modified derivative of adenosine where a fluorine atom replaces the hydroxyl group at the 3' position of the sugar moiety. This structural modification is critical for imparting unique biochemical properties, making it a valuable intermediate in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, oncology research, and as a building block for novel oligonucleotide synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways and polymerase activity.
• Proteomics & Molecular Biology: Serves as a modified building block for the synthesis of oligonucleotide probes and primers.
• Antiviral Agent Development: Investigated for its potential activity against a range of viral targets due to its mechanism of action as a chain terminator.
• Labeled Compound Synthesis: Acts as a precursor for the preparation of radiolabeled or fluorescently tagged compounds for diagnostic and tracking applications.

Basic Information

Product Name	3'-Fluoro-3'-Deoxyadenosine
CAS No.	75059-22-2
Molecular Formula	C10H12FN5O3
Molecular Weight	269.23 g/mol
Synonyms	3'-Fluoro-3'-deoxyadenosine; 9-[(2R,3R,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-amine; 3'-F-3'-dA; 3'-Fluoro-2',3'-dideoxyadenosine (common misnomer); Adenosine, 3'-fluoro-3'-deoxy-; 3'-Fluoro-ddA; 75059-22-2; 3'-F-ddA
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-3'-Deoxyadenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a comprehensive Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.