Description

Isothiocyanatoacetaldehyde Dimethyl Acetal is a versatile bifunctional building block containing both an isothiocyanate and an acetal-protected aldehyde group. This compound matters for its unique reactivity, enabling its use as a key intermediate in the synthesis of heterocyclic compounds and functionalized molecules. It is needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of thiazole, thiazolidine, and other sulfur- and nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Synthesis: Used in the development of novel active ingredients, including fungicides and herbicides, leveraging its reactive functional groups.
• Peptide Modification & Bioconjugation: The isothiocyanate group allows for selective reaction with amino groups, useful for labeling biomolecules or creating peptide-derived structures.
• Material Science Research: Serves as a precursor for functional polymers or dendrimers where controlled introduction of specific chemical handles is required.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes or affinity labels for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring the introduction of masked aldehyde and isothiocyanate functionalities in a single step.

Basic Information

Product Name	Isothiocyanatoacetaldehyde Dimethyl Acetal
CAS No.	75052-04-9
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	2-Isothiocyanato-1,1-dimethoxyethane; (Dimethoxymethyl)methyl isothiocyanate; Acetaldehyde, 2-isothiocyanato-, dimethyl acetal; NSC 334916; 1,1-Dimethoxy-2-isothiocyanatoethane; 2-Isothiocyanatoacetaldehyde dimethyl acetal; Isothiocyanatoacetaldehyde dimethyl acetal
EINECS	Contact for details

Quality Control

Our Isothiocyanatoacetaldehyde Dimethyl Acetal is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent hydrolysis of the acetal group.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.