Description

1-Arabinofuranosyl-5-Ethynylcytosine is a synthetic nucleoside analog with a modified cytosine base, distinguished by its arabinofuranosyl sugar moiety and an ethynyl group at the 5-position. This molecular architecture makes it a valuable intermediate and research chemical for developing novel antiviral and anticancer therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on nucleoside chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and DNA/RNA synthesis pathways.
• Antiviral Agent Development: Explored for its potential activity against DNA viruses due to its structural similarity to other active nucleoside analogs.
• Oncology Research: Investigated for its cytotoxic properties and potential to be incorporated into oligonucleotides for targeted cancer therapies.
• Prodrug Synthesis: Acts as a precursor for creating more bioavailable prodrug forms through chemical modifications.
• Molecular Biology: Potential use in creating labeled probes or modified nucleotides for diagnostic assays.

Basic Information

Product Name	1-Arabinofuranosyl-5-Ethynylcytosine
CAS No.	74954-66-8
Molecular Formula	C11H13N3O5
Molecular Weight	267.24 g/mol
Synonyms	5-Ethynyl-1-β-D-arabinofuranosylcytosine; 5-Ethynyl-ara-C; 1-(β-D-Arabinofuranosyl)-5-ethynylcytosine; 5-Ethynylcytosine arabinoside; NSC 718681; 5-Ethynyl-1-β-D-arabinofuranosyl-cytosine; 5-Ethynyl-arabinofuranosylcytosine
EINECS	Contact for details

Quality Control

Our 1-Arabinofuranosyl-5-Ethynylcytosine is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Standard quality control includes identity confirmation by spectroscopic methods and purity assessment by HPLC. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can supply material suitable for research and development purposes, with specifications aligned with industry standards for fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.