Description

2-Pyrrolidinecarbonyl Chloride, 5-Oxo-, (2S)- (9Ci) is a high-value chiral building block and activated carboxylic acid derivative. This compound is critical for the efficient synthesis of complex molecules, particularly in the pharmaceutical sector where stereochemical purity is paramount. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing active pharmaceutical ingredients (APIs) and other advanced intermediates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of proline-based drugs, enzyme inhibitors, and other bioactive molecules.
• Peptide Synthesis: Used as an activated ester precursor for coupling reactions in solid-phase and solution-phase peptide chemistry.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators with specific stereochemistry.
• Asymmetric Catalysis: Employed in the synthesis of chiral ligands and catalysts for stereoselective transformations.
• Material Science: Potential monomer or modifier for creating specialized polymers with unique properties.
• Academic & R&D: Fundamental reagent in organic chemistry research for method development and exploring new synthetic pathways.

Basic Information

Product Name	2-Pyrrolidinecarbonyl Chloride, 5-Oxo-, (2S)- (9Ci)
CAS No.	74936-93-9
Molecular Formula	C5H6ClNO2
Molecular Weight	147.56 g/mol
Synonyms	(S)-5-Oxopyrrolidine-2-carbonyl chloride; L-Pyroglutamoyl chloride; (S)-Pyroglutamic acid chloride; (2S)-5-Oxo-2-pyrrolidinecarbonyl chloride; (S)-2-Pyrrolidone-5-carboxylic acid chloride; (S)-PCA chloride; (S)-Pyroglutamyl chloride; L-Pyroglutamic acid chloride
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonyl Chloride, 5-Oxo-, (2S)- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. We adhere to cGMP principles where applicable to meet the stringent requirements of our global clientele in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic and highly volatile nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.