Description

Propyl Itraconazole is a synthetic triazole antifungal agent, specifically a derivative of itraconazole. This compound is significant for its role as a key pharmaceutical intermediate in the synthesis of advanced antifungal medications. It is primarily required by manufacturers in the pharmaceutical and fine chemical industries for research, development, and production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of itraconazole and related triazole antifungal APIs.
• Antifungal Drug Development: Used in research and development for creating new systemic antifungal agents targeting fungal cell membranes.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating the mechanism of action of azole antifungals and fungal sterol biosynthesis inhibition.
• Veterinary Medicine: Potential use in the formulation of antifungal treatments for veterinary applications.

Basic Information

Product Name	Propyl Itraconazole
CAS No.	74855-91-7
Molecular Formula	C35H38Cl2N8O4
Molecular Weight	705.63 g/mol
Synonyms	Propyl Itraconazole; 1-Propyl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-δ2-1,2,4-triazolin-5-one; Itraconazole Propyl Derivative; 4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1-propyl-δ2-1,2,4-triazolin-5-one; Propyl Itraconazole Impurity
EINECS	Contact for details

Quality Control

Our Propyl Itraconazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials and moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.