Description

α-Methyl-4-(2-Methylpropyl)Benzeneacetic Acid Trimethylsilyl Ester is a specialized organosilicon derivative of ibuprofen, serving as a key protected intermediate in advanced pharmaceutical synthesis. This compound matters for its role in enabling precise chemical modifications while safeguarding the carboxylic acid functionality, which is critical for developing novel active pharmaceutical ingredients (APIs) and prodrugs. It is primarily needed by research chemists and process development teams in the pharmaceutical and fine chemical industries for synthetic route development and scale-up.

Application

• Pharmaceutical Intermediate: A crucial protected synthon in the multi-step synthesis of novel non-steroidal anti-inflammatory drugs (NSAIDs) and their analogs.
• Prodrug Research: Used in the design and development of prodrug candidates to enhance bioavailability or modify the release profile of active molecules.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by allowing selective reactions at other sites on the ibuprofen backbone.
• Process Chemistry: Employed in route scouting and optimization for the commercial-scale manufacturing of complex target molecules.
• Reference Standard: Serves as an analytical standard for quality control and method development in API production.
• Chemical Derivatization: Used in analytical chemistry for gas chromatography (GC) or mass spectrometry (MS) by converting acids to more volatile trimethylsilyl esters.

Basic Information

Product Name	α-Methyl-4-(2-Methylpropyl)Benzeneacetic Acid Trimethylsilyl Ester
CAS No.	74810-89-2
Molecular Formula	C16H26O2Si
Molecular Weight	278.47 g/mol
Synonyms	Ibuprofen Trimethylsilyl Ester; 2-[4-(2-Methylpropyl)phenyl]propanoic Acid Trimethylsilyl Ester; Trimethylsilyl Ibuprofen; TMS-Ibuprofen; α-Methyl-4-(isobutyl)benzeneacetic Acid TMS Ester; (±)-Ibuprofen Trimethylsilyl Ester; 2-(4-Isobutylphenyl)propionic Acid Trimethylsilyl Ester
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(2-Methylpropyl)Benzeneacetic Acid Trimethylsilyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.