Description

Imidazole-1-Carbonyl Chloride is a highly reactive and versatile acylating agent, primarily used for the synthesis of imidazole carbamates and ureas. Its core value lies in its ability to efficiently introduce the imidazole-1-carbonyl moiety, a key functional group in medicinal chemistry and advanced material science. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of protease inhibitors, kinase inhibitors, and other bioactive molecules containing imidazole carbamate or urea scaffolds.
• Agrochemical Synthesis: Used in the production of novel fungicides and herbicides where the imidazole moiety imparts specific biological activity.
• Peptide Modification: Employed as a coupling reagent or protecting group agent in peptide synthesis to modify amino acid side chains.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating functional polymers with specific ligand-binding properties.
• Material Science: Utilized in the surface functionalization of materials to introduce imidazole-based ligands for catalysis or sensing applications.
• Chemical Biology Probes: Critical for labeling proteins or other biomolecules with imidazole tags for study and detection.

Basic Information

Item	Details
Product Name	Imidazole-1-Carbonyl Chloride
CAS No.	74731-19-4
Molecular Formula	C4H3ClN2O
Molecular Weight	130.53 g/mol
Synonyms	1-Imidazolecarbonyl Chloride; 1H-Imidazole-1-carbonyl Chloride; Imidazole-1-Carboxylic Acid Chloride; 1-Carboxyimidazole Chloride; CDI-HCl (analogous to Carbonyldiimidazole hydrochloride); Imidazolyl Carbonyl Chloride; N-Imidazolylcarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Imidazole-1-Carbonyl Chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. While produced to high standards, this product is typically offered as a laboratory or technical grade chemical. Specifications can be aligned with customer requirements for specific research or development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.