Description

8-Azidoinosine 5'-Monophosphate is a chemically modified nucleotide analog, specifically a purine nucleoside monophosphate bearing an azido functional group. This compound is a critical building block and biochemical probe in life science research, enabling advanced studies in nucleic acid chemistry and enzymology. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and pharmaceutical development for applications such as photoaffinity labeling, cross-linking studies, and the synthesis of novel nucleotide-based inhibitors.

Application

• Biochemical Research Probe: Used as a photoaffinity labeling agent to study enzyme active sites, protein-nucleic acid interactions, and receptor-ligand binding mechanisms.
• Nucleic Acid Chemistry: Serves as a key intermediate in the synthesis of modified nucleotides and oligonucleotides for structure-activity relationship (SAR) studies.
• Enzymology Studies: Acts as a substrate analog to investigate the kinetics and specificity of nucleoside/nucleotide kinases, phosphorylases, and other metabolic enzymes.
• Drug Discovery: Employed in the development of potential antiviral or anticancer agents that target nucleotide metabolism pathways.
• Click Chemistry: The azido group allows for efficient conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and probe development.
• Metabolic Pathway Analysis: Used to trace and inhibit specific steps in purine salvage and biosynthesis pathways within cells.

Basic Information

Product Name	8-Azidoinosine 5'-Monophosphate
CAS No.	74721-48-5
Molecular Formula	C10H12N6O8P
Molecular Weight	366.21 g/mol
Synonyms	8-Azido-IMP; 8-Azidoinosine monophosphate; 8-N3-IMP; 8-Azidopurine ribonucleoside 5'-monophosphate; 8-Azido-9-β-D-ribofuranosylhypoxanthine 5'-monophosphate; 8-Azidoinosine 5'-(dihydrogen phosphate); 5'-IMP-8-azido
EINECS	Contact for details

Quality Control

Our 8-Azidoinosine 5'-Monophosphate is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to stringent internal quality standards to meet the demands of the research community. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the material under an inert atmosphere in a freezer.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.