Description

Ingenol-20-Isobutyrate is a semi-synthetic diterpenoid ester derived from the plant genus Euphorbia. This compound is a key intermediate and reference standard in pharmaceutical research, particularly for its role in the development of targeted topical therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, dermatology, and chemical synthesis. The consistent quality and reliable supply of this high-purity compound are critical for advancing drug discovery and development pipelines.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the quality control and analytical method development of ingenol mebutate and related pharmaceutical actives.
• Active Pharmaceutical Ingredient (API) Intermediate: Used as a key synthetic precursor in the manufacture of ingenol mebutate (Picato®), a topical treatment for actinic keratosis.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate protein kinase C (PKC) modulation, apoptosis, and mechanisms of action in various cell lines.
• Dermatology R&D: A vital tool for researching novel topical formulations and delivery systems for the treatment of pre-cancerous and cancerous skin lesions.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and validation for the efficient synthesis of ingenol-based compounds.

Basic Information

Product Name	Ingenol-20-Isobutyrate
CAS No.	74690-91-8
Molecular Formula	C24H34O6
Molecular Weight	418.53 g/mol
Synonyms	Ingenol 20-Isobutyrate; 20-Isobutyryloxyingenol; Ingenol-3-angelate-20-isobutyrate (related); (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-Dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl 2-methylpropanoate; Ingenol ester; PEP005 Impurity (related)
EINECS	Contact for details

Quality Control

Our Ingenol-20-Isobutyrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.