Description

4-Azido-α-Diazoacetophenone is a highly reactive and specialized organic compound featuring both azido and diazo functional groups. This unique bifunctional structure makes it a valuable building block and photoaffinity labeling reagent in advanced chemical synthesis and biochemical research. It is primarily sought after by research chemists and process development scientists working in pharmaceutical discovery and materials science. The compound's reactivity profile enables its use in click chemistry and photochemical applications for probing molecular interactions.

Application

• Photoaffinity Labeling (PAL): A critical reagent for mapping biological binding sites and protein-ligand interactions due to its light-sensitive diazo and azido groups.
• Click Chemistry Precursor: Serves as a versatile intermediate for Huisgen 1,3-dipolar cycloaddition reactions, facilitating the synthesis of complex triazole-containing molecules.
• Pharmaceutical Research: Used in the discovery and development stages to create novel bioactive compounds and probe drug-target engagement.
• Polymer & Materials Science: Employed in the synthesis of functional polymers and advanced materials where photo-crosslinking or specific azide chemistry is required.
• Chemical Biology Probes: Integral to the development of activity-based probes for studying enzyme mechanisms and metabolic pathways.
• Agrochemical Intermediate: Potential use in the synthesis of novel crop protection agents with specific modes of action.

Basic Information

Product Name	4-Azido-α-Diazoacetophenone
CAS No.	74686-86-5
Molecular Formula	C8H5N5O
Molecular Weight	187.16 g/mol
Synonyms	4-Azido-α-diazoacetophenone; 4-Azidophenyldiazomethyl Ketone; p-Azido-α-diazoacetophenone; α-Diazo-4-azidoacetophenone; 1-(4-Azidophenyl)-2-diazoethan-1-one; 4-Azidobenzoyldiazomethane; (4-Azidophenyl)(diazomethyl)methanone; Diazomethyl 4-azidophenyl ketone
EINECS	Contact for details

Quality Control

Every batch of 4-Azido-α-Diazoacetophenone is manufactured and tested under strict quality management protocols to ensure high purity and consistent performance. Our products undergo rigorous analytical testing, including HPLC, NMR, and FTIR, to confirm identity and purity while monitoring for key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We adhere to cGMP principles for research chemicals, ensuring traceability and reliability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize decomposition and oxidation. The container should be kept in a freezer dedicated for chemicals, away from heat and ignition sources. Allow the container to reach room temperature in a dark environment before opening to prevent condensation and thermal shock.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (DMSO, DMF, Acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.