Description

6-Thioguanosine-5'-o-Monophosphate Sodium Salt is a chemically modified nucleotide analog of significant research and pharmaceutical interest. This compound serves as a critical biochemical tool for studying nucleotide metabolism and enzyme mechanisms, particularly those involving purine salvage pathways. It is primarily utilized by researchers and developers in the fields of biochemistry, molecular biology, and medicinal chemistry for the synthesis of novel probes and potential therapeutic agents.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for nucleotidase and kinase assays.
• Medicinal Chemistry: Serves as a key intermediate in the synthesis of nucleotide-based prodrugs and antiviral or anticancer candidates.
• Molecular Biology: Employed in the study of RNA modification and processing pathways due to its thioguanosine moiety.
• Diagnostic Reagent Development: Potential use in formulating kits for enzymatic activity detection and metabolic disorder diagnostics.
• Reference Standard: Acts as a high-purity analytical standard for quality control in pharmaceutical development and research publications.

Basic Information

Product Name	6-Thioguanosine-5'-o-Monophosphate Sodium Salt
CAS No.	74686-78-5
Molecular Formula	C10H12N5O7PS2Na2 (or related hydrate)
Molecular Weight	Contact for details
Synonyms	6-Thio-GMP Sodium Salt; 6-Thioguanosine 5'-Monophosphate Disodium Salt; 6-TGMP Na Salt; 6-SH-GMP Sodium Salt; 2-Amino-6-mercapto-9-β-D-ribofuranosylpurine 5'-monophosphate sodium salt; Guanosine-5'-monophosphate, 6-thio-, sodium salt; 6-Thioguanosine 5'-(disodium phosphate)
EINECS	Contact for details

Quality Control

Our 6-Thioguanosine-5'-o-Monophosphate Sodium Salt is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize condensation and moisture uptake. For extended storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.