Description

1,2'-o-Dimethyl Guanosine is a chemically modified nucleoside derivative of guanosine, featuring methylation at specific oxygen positions. This modification is crucial for enhancing the stability and altering the biological activity of oligonucleotides in research and therapeutic development. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions engaged in nucleic acid chemistry, antiviral drug discovery, and the synthesis of modified RNA analogs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies investigating RNA structure, function, and stability, including research on mRNA vaccines and therapeutics.
• Proteomics & Genomics: Serves as a modified substrate in enzymatic studies and for probing nucleic acid-protein interactions.
• Antisense Oligonucleotide Synthesis: Incorporated into oligonucleotides to enhance nuclease resistance and modulate binding affinity.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for sensitive detection and diagnostic assays.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in regulatory submissions.

Basic Information

Product Name	1,2'-o-Dimethyl Guanosine
CAS No.	74466-66-3
Molecular Formula	C₁₂H₁₇N₅O₅
Molecular Weight	311.30 g/mol
Synonyms	1,2'-Di-O-methylguanosine; Guanosine, 1,2'-di-O-methyl-; 1,2'-O-Dimethylguanosine; 2'-O-Methyl-1-methylguanosine; 1-Methyl-2'-O-methylguanosine; N1,2'-O-Dimethylguanosine; DMG (context-specific abbreviation)
EINECS	Contact for details

Quality Control

Our 1,2'-o-Dimethyl Guanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.