Description

1H-Indole, 2,3,5-Trimethyl-1-(Trimethylsilyl)- CAS NO 74367-58-1 is a high-purity, organosilicon-functionalized indole derivative, a key advanced intermediate in modern organic synthesis. Its value lies in providing a protected, reactive scaffold for constructing complex heterocyclic systems, particularly in pharmaceutical research and development. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to innovate with novel indole-based architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncological pathways.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides that leverage the indole core for enhanced biological activity.
• Material Science Research: Acts as a precursor for functionalized organic semiconductors and photochromic materials due to the electron-donating properties of the trimethylsilyl-protected indole system.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and other metal-mediated transformations to introduce complex indole motifs.
• Chemical Biology Probes: Utilized in the development of fluorescent tags and molecular probes for studying biological processes and enzyme interactions.

Basic Information

Product Name	1H-Indole, 2,3,5-Trimethyl-1-(Trimethylsilyl)-
CAS No.	74367-58-1
Molecular Formula	C14H21NSi
Molecular Weight	231.41 g/mol
Synonyms	1-(Trimethylsilyl)-2,3,5-trimethyl-1H-indole; 2,3,5-Trimethyl-1-(trimethylsilyl)indole; 1H-Indole, 2,3,5-trimethyl-1-(trimethylsilyl)-; 1-Trimethylsilyl-2,3,5-trimethylindole; N-Trimethylsilyl-2,3,5-trimethylindole; 2,3,5-Trimethyl-1-trimethylsilylindole; TMS-Protected 2,3,5-Trimethylindole
EINECS	Contact for details

Quality Control

Our 1H-Indole, 2,3,5-Trimethyl-1-(Trimethylsilyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.