Description

1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester is a highly functionalized, multi-silylated indole derivative designed for advanced synthetic chemistry. This compound is a critical protected intermediate, offering enhanced solubility and stability for complex organic transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and serotonin receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides with indole core structures.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic electronics and advanced polymers.
• Academic & Industrial R&D: A versatile reagent for methodological studies in organosilicon chemistry and protective group strategies.
• Process Chemistry: Employed in route scouting and scale-up for the efficient production of target molecules where silyl protection is required.

Basic Information

Product Name	1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester
CAS No.	74367-47-8
Molecular Formula	C20H33NO3Si3
Molecular Weight	431.73 g/mol
Synonyms	5-Hydroxy-1H-indole-2-carboxylic acid 1,2-bis(trimethylsilyl) ester; 1,2-Bis-O-trimethylsilyl-5-hydroxyindole-2-carboxylate; Tris(trimethylsilyl) 5-hydroxyindole-1,2-dicarboxylate; 5-(Trimethylsiloxy)-1-(trimethylsilyl)-1H-indole-2-carboxylic acid trimethylsilyl ester; TMS-protected 5-hydroxyindole-2-carboxylate; 74367-47-8; Indole-2-carboxylic acid, 5-hydroxy-, 1,2-bis(trimethylsilyl) ester
EINECS	Contact for details

Quality Control

Every batch of 1-(Trimethylsilyl)-5-[(Trimethylsilyl)Oxy]-1H-Indole-2-Carboxylic Acid Trimethylsilyl Ester is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation upon prolonged exposure to air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.