Description

[[16β,17β-Epoxyestra-1,3,5(10)-Trien-3-Yl]Oxy]Trimethylsilane is a high-purity, organosilicon-modified steroid derivative, serving as a critical advanced intermediate in pharmaceutical synthesis. Its core value lies in enabling precise chemical modifications to the steroidal backbone, which is essential for developing novel therapeutic agents with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical manufacturers focused on developing hormone-based therapies, anti-inflammatory drugs, and other specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroidal drugs and hormone analogs.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities.
• Steroid Derivative Synthesis: Facilitates the introduction of the trimethylsilyl ether protecting group at the 3-position, allowing for further selective functionalization of the steroidal core.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex steroid-based molecules in GMP environments.

Basic Information

Product Name	[[16β,17β-Epoxyestra-1,3,5(10)-Trien-3-Yl]Oxy]Trimethylsilane
CAS No.	74299-44-8
Molecular Formula	C23H34O2Si
Molecular Weight	370.60 g/mol
Synonyms	16β,17β-Epoxyestra-1,3,5(10)-trien-3-yloxytrimethylsilane; 3-Trimethylsilyloxy-16β,17β-epoxyestra-1,3,5(10)-triene; Estra-1,3,5(10)-trien-3-ol, 16β,17β-epoxy-, 3-(trimethylsilyl) ether; (16β,17β-Epoxyestra-1,3,5(10)-trien-3-yloxy)trimethylsilane; Trimethyl((16β,17β-epoxyestra-1,3,5(10)-trien-3-yl)oxy)silane
EINECS	Contact for details

Quality Control

Our [[16β,17β-Epoxyestra-1,3,5(10)-Trien-3-Yl]Oxy]Trimethylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods (NMR, IR), to ensure it meets the high standards required for pharmaceutical R&D and synthesis. Certificates of Analysis (COA) with detailed batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.