Description

9-(4-Thio-β-D-Ribofuranosyl)Guanine is a modified nucleoside analog, a key building block in medicinal chemistry and biochemical research. This compound is valued for its role as a precursor in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA repair mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in nucleoside chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving polymerases and kinases.
• Proteomics & Molecular Biology: Serves as a modified base for oligonucleotide synthesis to study nucleic acid structure, function, and protein interactions.
• Antiviral Agent Development: Investigated for its potential activity against DNA and RNA viruses due to its thio-modified ribose moiety.
• Labeled Compound Synthesis: Starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing studies.
• Library Synthesis: Building block for creating diverse chemical libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	9-(4-Thio-β-D-Ribofuranosyl)Guanine
CAS No.	74249-68-6
Molecular Formula	C10H13N5O4S
Molecular Weight	299.31 g/mol
Synonyms	4'-Thioguanosine; 9-[(4-Thio-β-D-ribofuranosyl)]guanine; 4'-Thio-β-D-ribofuranosylguanine; 4'-Thio-Guanosine; Guanosine, 4'-thio-; 4'-Thio-β-D-ribofuranosylguanine; β-4'-Thioguanosine
EINECS	Contact for details

Quality Control

Our 9-(4-Thio-β-D-Ribofuranosyl)Guanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.