Description

5-Fluorouracil Glucuronamide is a key glucuronide metabolite of the widely used chemotherapeutic agent 5-Fluorouracil (5-FU). This compound is of significant interest in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and the mechanisms of action and resistance associated with 5-FU-based therapies. It serves as a critical reference standard and intermediate for researchers and manufacturers in the oncology and pharmaceutical sectors, enabling precise analytical work and the development of next-generation therapeutic strategies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantitative and qualitative analysis of 5-FU metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• Metabolism and Pharmacokinetic Studies: Essential for investigating the metabolic pathways, bioavailability, and clearance mechanisms of 5-Fluorouracil in preclinical and clinical research.
• Drug Development Intermediate: Acts as a synthetic precursor or biochemical tool in the research and development of novel fluoropyrimidine-based anticancer agents or prodrugs.
• Biochemical Research: Employed in enzymatic studies to understand the activity of glucuronosyltransferases and other enzymes involved in nucleoside analog metabolism.
• Toxicology and Safety Assessment: Utilized to identify and quantify metabolite profiles for comprehensive toxicological evaluation of 5-FU treatments.

Basic Information

Product Name	5-Fluorouracil Glucuronamide
CAS No.	74240-89-4
Molecular Formula	C10H12FN3O8
Molecular Weight	321.22 g/mol
Synonyms	5-FU Glucuronamide; 5-Fluorouracil β-D-Glucuronide Amide; 1-[(2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl]-5-fluoropyrimidine-2,4-dione; 5-Fluorouracil 1-β-D-Glucuronamide; 5-Fluorouridine Glucuronide Amide; β-Glucuronidase Substrate Analog; 5-FU-GA
EINECS	Contact for details

Quality Control

Our 5-Fluorouracil Glucuronamide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development projects requiring material meeting specific research-grade or analytical reference material specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the product at 2-8°C. The container should be kept in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.