Description

(14S)-12β-Acetyloxy-3β,14-Dihydroxy-11α-[(3-Methyl-1-Oxobutyl)Oxy]Pregn-5-En-20-One CAS NO 74198-29-1 is a high-purity, semi-synthetic pregnane derivative, a critical intermediate in advanced pharmaceutical synthesis. Its complex, multi-functional steroid backbone makes it an invaluable precursor for the development of novel therapeutic agents, particularly in the field of endocrinology and anti-inflammatory drugs. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the synthesis of specialized steroid-based APIs and reference standards.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Serves as a precursor or substrate in metabolic pathway studies and enzyme inhibition assays related to steroid hormones.
• Process Development: Employed in scaling up and optimizing synthetic routes for complex steroid molecules in pilot plants and manufacturing facilities.
• Academic Research: Utilized in university and institutional labs for exploring new synthetic methodologies and structure-activity relationships (SAR) of pregnane derivatives.

Basic Information

Product Name	(14S)-12β-Acetyloxy-3β,14-Dihydroxy-11α-[(3-Methyl-1-Oxobutyl)Oxy]Pregn-5-En-20-One
CAS No.	74198-29-1
Molecular Formula	C29H42O7
Molecular Weight	502.64 g/mol
Synonyms	12β-Acetoxy-3β,14-dihydroxy-11α-(3-methyl-1-oxobutoxy)pregn-5-en-20-one; 3β,14-Dihydroxy-12β-acetoxy-11α-isovaleryloxypregn-5-en-20-one; 11α-Isovaleryloxy-12β-acetoxy-3β,14-dihydroxypregn-5-en-20-one; (14S)-12β-Acetoxy-3β,14-dihydroxy-11α-isovaleryloxypregn-5-en-20-one; Pregn-5-ene-20-one, 12β-(acetyloxy)-3β,14-dihydroxy-11α-[(3-methyl-1-oxobutyl)oxy]-, (11α,12β,14S)-; A derivative of Hecogenin or Tigogenin.
EINECS	Contact for details

Quality Control

Every batch of (14S)-12β-Acetyloxy-3β,14-Dihydroxy-11α-[(3-Methyl-1-Oxobutyl)Oxy]Pregn-5-En-20-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation, including a detailed Certificate of Analysis (COA) specifying purity, identity, and impurity profiles as determined by advanced chromatographic (HPLC, GC) and spectroscopic (NMR, IR, MS) techniques. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical R&D and GMP-grade intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.