Description

Cyclopropanecarboxylic Acid, 2-(Chlorocarbonyl)-, trans- (9Ci) is a specialized chiral building block and reactive intermediate of significant interest in advanced organic synthesis. Its core value lies in the presence of both a reactive acid chloride group and a strained cyclopropane ring, enabling the efficient construction of complex, stereodefined molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity, stereochemically defined intermediates for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing cyclopropane motifs, which are prevalent in various therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane structure can contribute to biological activity.
• Chiral Ligand & Catalyst Preparation: Serves as a precursor for synthesizing chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Material Science Research: Employed in the development of specialty polymers and functional materials with unique properties derived from the incorporated cyclopropane unit.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) working on client-specific molecular targets.
• Academic & R&D Laboratories: Used in methodological studies and for exploring new chemical reactions involving strained ring systems and acylating agents.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxylic Acid, 2-(Chlorocarbonyl)-, trans- (9Ci)
CAS No.	74177-20-1
Molecular Formula	C5H5ClO3
Molecular Weight	148.54 g/mol
Synonyms	(1R,2R)-2-(Chlorocarbonyl)cyclopropane-1-carboxylic Acid; trans-2-(Chlorocarbonyl)cyclopropanecarboxylic Acid; (1R,2R)-2-(Chloroformyl)cyclopropane-1-carboxylic Acid; trans-1,2-Cyclopropanedicarboxylic Acid Chloride (ambiguous); trans-Cyclopropane-1,2-dicarboxylic Acid Monochloride; (1R,2R)-Cyclopropane-1,2-dicarboxylic Acid 1-Chloride; 74177-20-1; trans-2-Carboxycyclopropanecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-(Chlorocarbonyl)-, trans- (9Ci) is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are available upon request, providing full traceability and quality assurance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its moisture-sensitive (hygroscopic) nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.