Description

5-(2-Chlorovinyl)-2'-Deoxyuridine is a modified nucleoside analog with significant research and pharmaceutical development potential. This compound is valued for its role as a key synthetic intermediate and its biological activity in targeted therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral and anticancer drug discovery, as well as in advanced biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral and antineoplastic (anticancer) prodrugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleoside metabolism and DNA synthesis pathways.
• Antiviral Agent Development: Investigated for its potential activity against herpesviruses and other DNA viruses due to its structural similarity to natural nucleosides.
• Radiopharmaceutical Precursor: Can be utilized in the development of radiolabeled compounds for diagnostic imaging or targeted radiotherapy.
• Academic & Industrial R&D: Employed in discovery chemistry for structure-activity relationship (SAR) studies to optimize drug candidates.

Basic Information

Product Name	5-(2-Chlorovinyl)-2'-Deoxyuridine
CAS No.	74131-08-1
Molecular Formula	C11H13ClN2O5
Molecular Weight	288.68 g/mol
Synonyms	CVDU; (E)-5-(2-Chlorovinyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-[(E)-2-chloroethenyl]pyrimidine-2,4-dione; 5-[(E)-2-Chloroethenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2'-Deoxy-5-(2-chlorovinyl)uridine; NSC 382577
EINECS	Contact for details

Quality Control

Our 5-(2-Chlorovinyl)-2'-Deoxyuridine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development purposes. Standard analytical controls include HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.