Description

(E)-5-(2-Carboxyvinyl)-2'-Deoxyuridine is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a key intermediate and building block in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and DNA synthesis pathways. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of advanced nucleoside analogs for antiviral and anticancer drug discovery.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving thymidylate synthase or viral polymerases.
• Antiviral Agent Development: Serves as a core structure for developing prodrugs targeting herpesviruses, hepatitis B virus (HBV), and other DNA viruses.
• Anticancer Research: Investigated for its potential to be incorporated into DNA, inhibiting tumor cell proliferation.
• Probe Synthesis: Utilized in creating labeled compounds (e.g., fluorescent or radioactive probes) for molecular biology and diagnostic assays.
• Medicinal Chemistry: A versatile building block for structure-activity relationship (SAR) studies to optimize potency and selectivity of drug candidates.

Basic Information

Product Name	(E)-5-(2-Carboxyvinyl)-2'-Deoxyuridine
CAS No.	74131-06-9
Molecular Formula	C₁₂H₁₄N₂O₇
Molecular Weight	298.25 g/mol
Synonyms	5-(2-Carboxyethenyl)-2'-deoxyuridine; (E)-5-(2-Carboxyvinyl)-2'-deoxyuridine; 5-Carboxyvinyl-2'-deoxyuridine; 5-(2-Carboxyvinyl)dUrd; 5-CV-dU; NSC 380292; 2'-Deoxy-5-(2-carboxyvinyl)uridine; (E)-5-(2-Carboxyethenyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our (E)-5-(2-Carboxyvinyl)-2'-Deoxyuridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.