Description

Ditekiren is a potent and selective renin inhibitor, a key compound in cardiovascular and renal research. Its primary value lies in its ability to specifically target the renin-angiotensin system, making it a critical tool for investigating hypertension and related pathologies. This high-purity compound is essential for pharmaceutical R&D, academic research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel antihypertensive drugs.
• Biochemical Assays: Used as a specific inhibitor in enzymatic studies to elucidate the role of renin in the angiotensinogen conversion pathway.
• Preclinical Studies: Employed in animal models to study the efficacy, pharmacokinetics, and pharmacodynamics of renin inhibition for treating hypertension and heart failure.
• Mechanism of Action (MOA) Studies: A vital tool for understanding the structure-activity relationship (SAR) of renin inhibitors and for validating new drug targets.
• Quality Control Laboratories: Utilized as an analytical reference standard for the identification and quantification of ditekiren in bulk substances and finished dosage forms.

Basic Information

Product Name	Ditekiren
CAS No.	103336-05-6
Molecular Formula	C35H49N5O7
Molecular Weight	651.80 g/mol
Synonyms	Ditekiren; U-71038; (2S,4S,5S)-5-Amino-6-cyclohexyl-N-[(2S,4S)-1-[(2S)-2-[[(4-methoxyphenyl)sulfonyl]amino]-1-oxo-3-phenylpropyl]-4-(3-pyridinylmethyl)-2-piperidinyl]-2-methyl-4-(methylamino)hexanamide; 1-(N-[(4-Methoxyphenyl)sulfonyl]-L-phenylalanyl)-4-(3-pyridinylmethyl)-L-prolyl-cyclohexylnorstatine; Renin Inhibitor U-71038
EINECS	Contact for details

Quality Control

Our Ditekiren is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.