Description

1-[(2R,4R,5S)-4-Azido-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-Dione is a sophisticated nucleoside analogue derivative, a key building block in advanced pharmaceutical research and development. Its precise stereochemistry and functional groups make it a critical intermediate for the synthesis of novel antiviral and anticancer agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing next-generation therapeutics targeting viral replication and cellular proliferation.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of modified nucleoside analogues for antiviral and anticancer drug discovery.
• Antiviral Pro-drug Development: Used in research to create prodrugs and active metabolites targeting viruses such as HIV, hepatitis, and herpes.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to DNA/RNA synthesis and repair mechanisms.
• Labeled Compound Synthesis: Acts as a starting material for introducing azide or other functional handles for click chemistry and bioconjugation applications.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of nucleoside-based therapeutics.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research in organic chemistry and pharmacology.

Basic Information

Product Name	1-[(2R,4R,5S)-4-Azido-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-Dione
CAS No.	73971-82-1
Molecular Formula	C10H13N5O5
Molecular Weight	283.24 g/mol
Synonyms	4-Azido-5-(hydroxymethyl)-2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl azide (stereoisomer); 3'-Azido-3'-deoxy-5-methyluridine intermediate; AZT precursor analogue; 1-[(2R,4R,5S)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 5-Methyl-1-[(2R,4R,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and pharmaceutical development. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and MS to ensure structural identity and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profile, and results from all specified tests. Our quality system is designed to support cGMP compliance for customers requiring material for preclinical and clinical-stage manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Store away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.