Description

1-(3-β-Amino-2,3-Dideoxy-β-D-Threopenta-Furanosyl)Thymine is a specialized nucleoside analogue, a key building block in advanced pharmaceutical and biochemical research. Its modified sugar backbone is critical for developing novel antiviral and anticancer agents, particularly in the synthesis of nucleoside reverse transcriptase inhibitors. This high-purity intermediate is essential for research and development laboratories, pharmaceutical manufacturers, and biotechnology companies focused on next-generation therapeutic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral drugs, including nucleoside analogues targeting viral polymerases.
• Anticancer Agent Research: Used in the development and study of chemotherapeutic compounds that interfere with DNA synthesis in rapidly dividing cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies, particularly those involving DNA polymerases and related enzymes.
• Prodrug Development: Employed in the design of prodrugs to improve the bioavailability and targeting of active nucleoside therapeutics.
• Molecular Biology: Used in the synthesis of modified oligonucleotides for probing nucleic acid structure and function.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory compliance in pharmaceutical manufacturing.

Basic Information

Product Name	1-(3-β-Amino-2,3-Dideoxy-β-D-Threopenta-Furanosyl)Thymine
CAS No.	73971-79-6
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	3'-Amino-2',3'-dideoxythymidine; 3'-Amino-2',3'-dideoxy-D-threo-pentofuranosyl thymine; 1-[(2S,4S,5R)-4-Amino-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 3'-Amino-2',3'-dideoxy-D-threo-pentofuranosylthymine; 3'-Amino-2',3'-dideoxy-D-threo-pentofuranosyl-1-thymine; 3'-Amino-2',3'-dideoxythymidine (D-Threo); ADDT; Contact for additional aliases.
EINECS	Contact for details

Quality Control

Our 1-(3-β-Amino-2,3-Dideoxy-β-D-Threopenta-Furanosyl)Thymine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific pharmaceutical (GMP) or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.