Description

5-Azidonaphthalene-1-Sulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative featuring a reactive azido group. This bifunctional reagent is critical for introducing photoactivatable or click chemistry handles into target molecules, enabling advanced bioconjugation and materials science research. It is primarily utilized by researchers and process development scientists in the pharmaceutical, biotech, and advanced materials sectors for labeling, crosslinking, and polymer modification applications.

Application

• Photoaffinity Labeling Probes: Acts as a key precursor for synthesizing photoaffinity labels to study protein-ligand interactions and binding sites.
• Bioconjugation Linker: Used to attach reporter molecules (e.g., fluorophores, biotin) to proteins, antibodies, or other biomolecules via its sulfonyl chloride group, with the azide enabling subsequent "click" chemistry.
• Polymer Functionalization: Employed to modify polymer backbones, introducing azide functionalities for creating smart materials, hydrogels, or surface coatings.
• Chemical Biology Tool Development: Serves as a building block for creating activity-based probes (ABPs) and other chemical tools to interrogate biological pathways.
• Peptide and Protein Modification: Facilitates site-specific modification of peptides and proteins for therapeutic or diagnostic purposes.
• Materials Crosslinking: Utilized in crosslinking reactions to enhance the mechanical properties or create specific network structures in advanced materials.

Basic Information

Product Name	5-Azidonaphthalene-1-Sulfonyl Chloride
CAS No.	73936-73-9
Molecular Formula	C10H6ClN3O2S
Molecular Weight	267.69 g/mol
Synonyms	1-Azido-5-naphthalenesulfonyl chloride; 5-Azido-1-naphthalenesulfonyl chloride; 1-Naphthalenesulfonyl chloride, 5-azido-; 5-Azidonaphthalene-1-sulfonyl chloride; NSC 401016; 5-Azidonaphthalenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Azidonaphthalene-1-Sulfonyl Chloride is manufactured under strict quality protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and light-sensitive nature, the material should be handled under inert atmosphere or dry conditions for long-term stability and to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.