Description

3-Azidostyryl-2'-Deoxyuridine 5-Phosphate is a modified nucleoside phosphate derivative, a critical building block in advanced biochemical research and development. This compound is specifically engineered for applications requiring photo-activatable or click chemistry-based labeling and crosslinking. It is essential for researchers and developers in the fields of medicinal chemistry, oligonucleotide synthesis, and the development of novel diagnostic probes and therapeutic agents.

Application

• Photoaffinity Labeling Probes: Used as a key reagent in the synthesis of photo-crosslinking probes for studying nucleic acid-protein interactions and biomolecular structures.
• Click Chemistry Substrates: Serves as an azide-functionalized building block for copper-catalyzed azide-alkyne cycloaddition (CuAAC) in bioconjugation and probe development.
• Antiviral & Anticancer Research: Investigated as a modified nucleoside analog precursor in the development of novel therapeutic agents targeting viral polymerases or cellular DNA synthesis.
• Oligonucleotide Synthesis: Incorporated into synthetic oligonucleotides to introduce specific, reactive handles for downstream labeling, immobilization, or structural modification.
• Diagnostic Assay Development: Utilized in the creation of sensitive detection systems, such as fluorescence quenching or FRET-based assays, for nucleic acid detection.
• Biophysical Studies: Acts as a tool compound for studying enzyme kinetics, binding affinities, and mechanisms of action of polymerases and other nucleic acid-processing enzymes.

Basic Information

Product Name	3-Azidostyryl-2'-Deoxyuridine 5-Phosphate
CAS No.	73847-63-9
Molecular Formula	C18H19N5O9P
Molecular Weight	504.35 g/mol
Synonyms	3-Azidostyryl-dUMP; 5'-O-Phosphono-3-(4-azidostyryl)-2'-deoxyuridine; 3-(4-Azidostyryl)-2'-deoxyuridine 5'-monophosphate; 3-Azidostyryl-2'-deoxyuridylic acid; 3-AS-dUMP; Azidostyryl dUMP; 3-(4-Azidophenyl)ethenyl-2'-deoxyuridine 5'-phosphate
EINECS	Contact for details

Quality Control

Our 3-Azidostyryl-2'-Deoxyuridine 5-Phosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep the primary container in a sealed secondary container with desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.