Description

N1,2'-o-Dimethylguanosine is a chemically modified nucleoside derivative, specifically a dimethylated analog of guanosine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a precursor or intermediate in the synthesis of modified RNA molecules and nucleoside-based therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in nucleic acid chemistry, epigenetics, and drug discovery programs.

Application

• Biochemical Research: Used as a critical building block in the study of RNA structure, function, and modification (epitranscriptomics).
• Pharmaceutical Intermediates: Serves as a key synthetic precursor in the development of novel antiviral and anticancer nucleoside analogs.
• Proteomics & Metabolomics: Acts as a standard or reference compound in mass spectrometry-based analytical studies.
• Enzyme Substrate Studies: Employed to investigate the activity and specificity of methyltransferase enzymes.
• Diagnostic Reagent Development: Potential use in the formulation of kits for detecting specific RNA modifications.
• Academic Research: Fundamental tool for universities and labs exploring nucleic acid biochemistry and molecular biology.

Basic Information

Product Name	N1,2'-o-Dimethylguanosine
CAS No.	73667-71-7
Molecular Formula	C₁₂H₁₇N₅O₅
Molecular Weight	311.30 g/mol
Synonyms	1,2'-O-Dimethylguanosine; 1-Methyl-2'-O-methylguanosine; N(1),2'-O-Dimethylguanosine; Guanosine, 1,2'-O-dimethyl-; 2'-O-Methyl-1-methylguanosine; 1-Methyl-2'-O-methyl-Guanosine; N1-Methyl-2'-O-methylguanosine; DMG (abbreviation in research contexts)
EINECS	Contact for details

Quality Control

Our N1,2'-o-Dimethylguanosine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.