Description

Adenosine 5'-o-(2-Thiodiphosphate) Trilithium Salt is a high-purity, chemically modified nucleotide analog where a sulfur atom replaces one of the non-bridging oxygen atoms in the diphosphate moiety, making it a valuable tool for studying ATP-dependent enzymes and signaling pathways. This compound is critical for researchers and manufacturers requiring a hydrolysis-resistant ATP analog to investigate enzyme mechanisms, particularly kinases and ATPases, without the risk of phosphate transfer. It is primarily utilized in biochemical research, pharmaceutical development for target validation, and the production of diagnostic assay kits where precise modulation of nucleotide-dependent processes is essential.

Application

• Biochemical Research: Used as a stable, non-hydrolyzable analog of ATP in enzymatic studies to probe the mechanisms of kinases, ATPases, and other ATP-binding proteins.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays and target validation for drug discovery programs focused on metabolic and signaling pathways.
• Diagnostic Reagents: A key component in the formulation of specialized assay kits for measuring enzyme activity or for use as a control in clinical diagnostics.
• Signal Transduction Studies: Essential for investigating purinergic signaling and the role of nucleotide derivatives in cellular communication.
• Enzyme Inhibitor Studies: Serves as a competitive inhibitor to understand substrate binding sites and to develop novel enzyme inhibitors.
• Academic & Institutional Research: Fundamental reagent for universities and research institutes conducting cutting-edge life science and molecular biology research.

Basic Information

Product Name	Adenosine 5'-o-(2-Thiodiphosphate) Trilithium Salt
CAS No.	73536-95-5
Molecular Formula	C10H12Li3N5O9P2S
Molecular Weight	479.09 g/mol
Synonyms	Adenosine-5'-[β-thio]diphosphate trilithium salt; Adenosine 5'-(2-thiodiphosphate) Li3 salt; ATPβS trilithium salt; 5'-Adenylyl (β-thio)diphosphate trilithium salt; Adenosine-5'-O-(2-thiodiphosphate); ADENOSINE-5'-DIPHOSPHOTHIOLATE TRILITHIUM SALT; ADENOSINE 5'-(2-THIODIPHOSPHATE); Non-hydrolyzable ATP analog trilithium salt
EINECS	Contact for details

Quality Control

Every batch of Adenosine 5'-o-(2-Thiodiphosphate) Trilithium Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the stringent requirements of research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), identity (by NMR/IR), and specific impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Heavy Metals	≤ 20 ppm
Biological Activity	Tested in standard kinase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.