Description

1-Arabinofuranosylcytosine-5'-Stearylphosphate is a chemically modified nucleoside analog, specifically a cytarabine derivative where the 5'-hydroxyl group is esterified with stearylphosphoric acid. This molecular design is significant for enhancing the lipophilicity and potentially the cellular uptake or prodrug properties of the parent compound. It is a critical intermediate and research chemical primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel antiviral or anticancer therapeutics, as well as by academic institutions conducting biochemical and pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based prodrugs and lipophilic conjugates aimed at improving drug delivery and bioavailability.
• Antiviral Research: Used in the development and study of potential antiviral agents, leveraging the mechanism of action of cytarabine derivatives against viral polymerases.
• Oncology Research: Investigated as a precursor for chemotherapeutic agents designed to target cancer cell DNA synthesis with modified pharmacokinetic profiles.
• Biochemical Tool: Employed in enzymatic and cellular studies to understand the metabolism and mechanism of action of phosphorylated nucleoside analogs.
• Lipid-Nucleic Acid Conjugate Synthesis: Acts as a specialized reagent for creating lipid-oligonucleotide conjugates used in gene delivery and therapeutic oligonucleotide research.
• Reference Standard: Utilized as a high-purity analytical standard in quality control and method development for pharmaceutical manufacturing.

Basic Information

Product Name	1-Arabinofuranosylcytosine-5'-Stearylphosphate
CAS No.	73532-83-9
Molecular Formula	C31H54N3O8P
Molecular Weight	627.75 g/mol
Synonyms	Stearyl Cytarabine 5'-Monophosphate; Cytarabine 5'-Stearylphosphate; 5'-O-Phosphonato-O-stearyl Cytarabine; 1-β-D-Arabinofuranosylcytosine 5'-Stearyl Ester Phosphoric Acid; Ara-CMP Stearyl Ester; NSC 281272 (Stearyl Derivative); Cytosine Arabinoside 5'-Stearylphosphate
EINECS	Contact for details

Quality Control

Our 1-Arabinofuranosylcytosine-5'-Stearylphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets high-purity research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.