Description

5-Amino-2'-Deoxyuridine Hydrochloride is a modified nucleoside analog of significant interest in biochemical and pharmaceutical research. Its core value lies in its role as a key intermediate and building block for the synthesis of novel antiviral and anticancer compounds. This high-purity chemical is essential for researchers and manufacturers in the fields of nucleoside chemistry, medicinal chemistry, and molecular biology. It is utilized in the development of diagnostic probes and therapeutic agents targeting viral replication and cellular proliferation.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA synthesis and repair mechanisms.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Molecular Probe Development: Acts as a precursor for labeled compounds used in diagnostic assays and imaging.
• Academic & Institutional Research: Employed in universities and research institutes for studying nucleotide metabolism and enzyme kinetics.

Basic Information

Product Name	5-Amino-2'-Deoxyuridine Hydrochloride
CAS No.	73446-40-9
Molecular Formula	C9H14N3O5 • HCl
Molecular Weight	289.69 g/mol (Free base: 253.22 g/mol)
Synonyms	5-Amino-2'-deoxyuridine HCl; 5-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione hydrochloride; 5-Amino-deoxyuridine hydrochloride; 5-NH2-dUrd HCl; 5-Amino-2'-deoxyuridine monohydrochloride
EINECS	Contact for details

Quality Control

Our 5-Amino-2'-Deoxyuridine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-process controls and final release testing protocols. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.